By "Overture" I'm assuming you're talking about the Yahoo Publisher program?
I use both... On this site, I use Adsense. On another site (gimmeanace.com) I use Yahoo. It seems that Adsense has a larger pool of ads to pull from, as the Yahoo ads seem to be displayed over and over again while the Adsense ads change more often.
The Yahoo ads seem to pay better, though.
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